Get the Flash Player to see this rotator.
  • Mission
    Statement
  • Research
    Highlights
  • Our
    Team
  • Overview

Mission Statement

PMRI is a non-profit research institute that performs scientific research investigating the effects of diet and lifestyle choices on health and disease.

Our work is grounded in compassion and dedication to service. PMRI achieves its mission by:

  • Publishing research that informs the practice of medicine and allows the individual to take personal responsibility for health
  • Collaborating with leaders in the scientific community
  • Educating and training health professionals and the public about preventive medicine and the benefits of lifestyle change

Research Highlight

Acknowledgement

We remain deeply grateful to the U.S. Army Medical Research and Materiel Command's Office of the Congressionally Directed Medical Research Programs (CDMRP) for making the research studies that are described below possible. Our work is described on page 9 of the 2008 CDMRP report and page 14 of the 2007 CDMRP report. We also appreciate the many foundations and individuals who support our work, without which it would not be possible.

Telomerase Study

"Increased telomerase activity and comprehensive lifestyle changes: a pilot study."

Results of this study, published in the journal Lancet Oncology (Lancet Oncology: www.lancet.com), showed, for the first time, that changing lifestyle significantly increases telomerase. Telomerase is the enzyme responsible for maintaining telomere length. Telomeres are the ends of chromosomes that influence how long we live. This is the first time that any intervention, even drugs, has been shown to significantly increase telomerase.

For a detailed summary of this study, please click here:Lancet Oncology: Study Summary

For the full text of this scientific article, please click here:Cadmus Communications: Full Text

Gene Expression Study

"Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention." Preceedings of the National Academy of Sciences (PNAS): www.pnas.org

In this study, published in the Proceedings of the National Academy of Sciences (www.pnas.org), we found that over 500 genes were affected by lifestyle changes. In fact, certain disease preventing genes were up-regulated, or turned on, and certain disease promoting genes, including oncogenes involved in cancer, were down-regulated, or turned off. The results of this study suggest that comprehensive lifestyle changes may cause changes in gene expression that could be beneficial to the general population as well as to those with prostate cancer.

For the full text of this scientific article, please click here:Preceedings of the National Academy of Sciences (PNAS): www.pnas.org

"Lifestyle changes and prostate cancer"
Journal of Urology (PDF)

We examined the effects of intensive lifestyle changes on men with early stage Prostate Cancer after 1 year. After 1 year, none of the men in the experimental group underwent conventional treatments compared to 6 in the control group. Prostate Specific Antigen (PSA) decreased 4% in the experimental group compared to a 6% increase in the control group, and prostate cancer cell growth was inhibited almost eight times as much in the experimental group compared to the control group. These results indicate that intensive lifestyle changes may effect the progression of early low grade prostate cancer.

"Intensive Lifestyle Changes for Reversal
of Coronary Heart Disease"

Journal of the American Medical Association (PDF)

We examined the ability of patients enrolled in the Lifestyle Heart Trial to sustain intensive lifestyle changes for a total of five years and the effects of these lifestyle changes on coronary heart disease. We measured adherence to lifestyle changes, changes in coronary artery percent diameter stenosis, and cardiac events. Outcomes in the experimental group showed significant improvement relative to controls. Additionally, compared to 1 year follow up, 5 year follow ups showed greater improvement relative to controls.

"Improvement in Medical Risk Factors and Quality of Life in Women and Men With Coronary Artery Disease in the Multicenter Lifestyle Demonstration Project"
American Journal of Cardiology (PDF)

We examined baseline and 3 month medical and psychosocial characteristics of women and men enrolled in the Multicenter Lifestyle Demonstration Project. Results showed significant improvements in diet, exercise and stress management, as well as improvements in medical and psychosocial characteristics. These improvements occured in spite of gender differences in medical, psychosocial and sociodemographic status. These results suggest that programs focusing on intensive lifestyle changes can be successfully implemented in diverse regions of the United States, and may be particularly helpful for women with heart disease, who generally have higher mortality and morbidity rates than men after a cardiac event.

"Avoiding Revascularization with Lifestyle Changes: The Multicenter Lifestyle Demonstration Project"
American Journal of Cardiology (PDF)

We examined the potential of intensive lifestyle changes as a direct alternative to revascularization procedures on patients enrolled in the Multicenter Lifestyle Demonstration Project. Results showed that patients in the experimental group were able to avoid revascularization for at least 3 years without increasing cardiac morbidity and mortality. These changes also came at a significantly lower cost than a revascularization procedure. These patients also reported experiencing reductions in angina similar to what was reported after a revascularization.

Nutriton

Staff Consultants
Dean Ornish - Founder & President
Anne Ornish - VP Outreach & Program Development
Colleen Kemp - VP Operations & Education
Josephine Doig - Director of Operations & Finance
Nita Chainani Wu - Senior Research Scientist
Rajni Banthia - Senior Project Director
Ivette S. Estay - Clinical Research Coordinator
Melanie Elliott-Eller - Clinical Nurse Specialist
Tandis Alizadeh - Project Coordinator
Jessica E. Knies - Administrative Assistant
Susi Amendola
Robert Avenson
Stacey Dunn-Emke
Joanne Frattaroli
Steven Frenda
Sarah Govil
Michael Lee
Lee Lipsenthal
Ruth Marlin
Jennifer McCrea
Terri Merritt-Worden
Kathy Ornish
Claudia Pischke
Gerdi Weidner

Dr. Dean OrnishDean Ornish, MD

Dean Ornish, M.D., is the founder and president of the non-profit Preventive Medicine Research Institute in Sausalito, California, where he holds the Safeway Chair. He is Clinical Professor of Medicine at the University of California, San Francisco. Dr. Ornish received his medical training in internal medicine from the Baylor College of Medicine, Harvard Medical School, and the Massachusetts General Hospital. He received a B.A. in Humanities summa cum laude from the University of Texas in Austin, where he gave the baccalaureate address.

For over 32 years, Dr. Ornish has directed clinical research demonstrating, for the first time, that comprehensive lifestyle changes may begin to reverse even severe coronary heart disease, without drugs or surgery. Recently, Medicare agreed to provide coverage for this program, the first time that Medicare has covered a program of comprehensive lifestyle changes. He directed the first randomized controlled trial demonstrating that comprehensive lifestyle changes may stop or reverse the progression of early-stage prostate cancer. His current research showed that comprehensive lifestyle changes affect gene expression, “turning on” disease-preventing genes and “turning off” genes that promote cancer and heart disease, as well as lengthening telomeres, the ends of chromosomes that control how long we live, in collaboration with Dr. Elizabeth Blackburn, who was awarded the Nobel Prize in Medicine in 2009.

He is the author of six best-selling books, including New York Times’ bestsellers Dr. Dean Ornish's Program for Reversing Heart Disease; Eat More, Weigh Less; Love & Survival; and his most recent book, The Spectrum.

The research that he and his colleagues conducted has been published in the Journal of the American Medical Association, The Lancet, Proceedings of the National Academy of Sciences, Circulation, The New England Journal of Medicine, the American Journal of Cardiology, and elsewhere.

A one-hour documentary of their work was broadcast on NOVA, the PBS science series, and was featured on Bill Moyers' PBS series, Healing & The Mind. Their work has been featured in all major media, including cover stories in Newsweek, Time, and U.S. News & World Report. He has written a monthly column for Newsweek and Reader’s Digest magazines and is Medical Editor of The Huffington Post, which has 22 million unique readers per month.

Dr. Ornish is a member of the boards of directors of the San Francisco Food Bank, the U.S. United Nations High Commission on Refugees, the J. Craig Venter Institute, and the advisory board of the Quincy Jones Foundation at the Harvard School of Public Health. He was appointed to the White House Commission on Complementary and Alternative Medicine Policy and elected to the California Academy of Medicine. He consults with food companies to make more healthful foods and to provide health education to their customers in this country and worldwide. He chairs the Google Health Advisory Council.

He has received several awards, including the 1994 Outstanding Young Alumnus Award from the University of Texas, Austin, the University of California, Berkeley, “National Public Health Hero” award, the Jan J. Kellermann Memorial Award for distinguished contribution in the field of cardiovascular disease prevention from the International Academy of Cardiology, a Presidential Citation from the American Psychological Association, the Beckmann Medal from the German Society for Prevention and Rehabilitation of Cardiovascular Diseases, the “Pioneer in Integrative Medicine” award from California Pacific Medical Center, the Golden Plate Award from the American Academy of Achievement, a U.S. Army Surgeon General Medal, and the Bravewell Collaborative Pioneer of Integrative Medicine award. Dr. Ornish has been a physician consultant to President Clinton since 1993 and to several bipartisan members of the U.S. Congress, and he consulted with the chefs at The White House, Camp David, and Air Force One to cook more healthfully (1993-2000). He is listed in Who’s Who in Healthcare and Medicine, Who’s Who in America, and Who’s Who in the World. He recently gave a keynote speech reviewing the science of integrative medicine at the Institute of Medicine’s Summit on Integrative Medicine at the National Academy of Sciences.

Dr. Ornish was recognized as “one of the most interesting people of 1996” by People magazine, selected as one of the “TIME 100” in integrative medicine, chosen by LIFE magazine as “one of the fifty most influential members of his generation” and by Forbes magazine as “one of the seven most powerful teachers in the world.”

back to all staff

Anne OrnishAnne Ornish, BA, IAYT

Anne Ornish is Vice President of the non-profit Preventive Medicine Research Institute where she directs Outreach and Program Development.

She is a certified Integrative Health and Spirituality practitioner through the California Pacific Medical Center's Institute for Health and Healing's hospital training program. She has also received professional training Mindfulness-Based Stress Reduction in Mind-Body Medicine with Dr. Jon Kabat-Zinn of the University of Massachusetts Stress Reduction Clinic. She completed the Academy for Interactive Guided Imagery's two-year certification program.

After receiving her post-graduate degree in web production, she produced the online platforms for the Ornish Program at WebMD from 1998-2006.

Anne passionately embarked on the path of yoga in 1993. Her years as an avid yoga practitioner and therapist have trained her in the various stress management techniques integral to Dean Ornish, MD's landmark program of comprehensive changes in diet and lifestyle, such as therapeutic stretching, meditation, guided imagery and breath awareness. Her purpose for teaching yoga as stress management is to heighten overall awareness in ways that can transform how one relates and responds to stress into more skillful, sustainable and joyous ways of being.

Website: http://www.anneornish.com

back to all staff

Colleen KempColleen Kemp, RN, MSN

Colleen Kemp is the VP of Operations and Education. She has been a practicing registered nurse since 1980. In 2002 she graduated from Dominican University of California with a Masters in Nursing, and certification as a Clinical Nurse Specialist in Integrative Health. She is nationally board certified as a Holistic Nurse. Her hospital experience includes working in the Intensive Care and the Post Anesthesia Care Units. She worked as a Clinic Nurse at PacifiCare Wellness where she performed screening health exams and educated individuals on lifestyle modification. She has produced a series of lecture events and home study programs with a focus on Integrative health care choices. She holds an adjunct faculty position in the Nursing Department at Dominican University. She joined PMRI in 2002 and has served in a variety of roles, including Director of Operations. She currently serves as Project Director for the Gene Expression Modulation in Nutrition and Lifestyle (GEMINAL) study.

back to all staff

Josephine DoigJosephine Doig

Josephine Doig is the Director of Operations and Finance for the Preventive Medicine Research Institute.

For the past 10 years, she has been consulting for a variety of organizations in the Accounting, Project Management, Organizational and Creative Direction fields. Prior to that she has had an extensive background in Interactive Media as a Producer managing budgets, teams and schedules for high level projects in the Business, Health and Wellness and Entertainment industries.

She has studied mindfulness for the past 12 years and has a deep commitment to bringing more consciousness to all aspects of her life. Her main teachers have included Jack Kornfield and Lama Tsultrim Allione.

She is dedicated to community service, volunteering for a number of non-profit organizations in the Bay Area. She balances her work life with a rich creative life as a Transformational Artist, Dancer, Poet and Vocalist.

back to all staff

NitaNita Chainani-Wu, DMD, MS, PhD

Nita Chainani-Wu received her DMD from the University of Pennsylvania in 1996. She then completed her specialty training in Oral Medicine (2000) and a Master's in Science in Oral Biology (2001) from the University of California, San Francisco. She received her PhD in Epidemiology from the School of Public Health, University of California, Berkeley in 2005. She has been on the faculty at the University of California, San Francisco since 2001 and has been in private practice in oral medicine in Sunnyvale since 2000. She has published on the role of diet in oral, pharyngeal and esophageal cancers, oral lichen planus, the association of oral lichen planus and hepatitis C virus, integrin expression in hairy leukoplakia, safety and anti-inflammatory activity of curcuminoids and their use in oral lichen planus, sialogogue use in xerostomia, and validation of instruments for measurement of signs and symptoms of oral lichen planus. Her current research interests include the role of diet and lifestyle factors in oral and systemic diseases. Dr Chainani-Wu joined PMRI in 2008 and currently serves as Staff Research Associate.

back to all staff

RajniRajni Banthia, PhD

Rajni Banthia is Senior Project Director at PMRI. Prior to joining the team at PMRI, she was a Health Policy Associate at PolicyLink, a nonprofit research and advocacy organization, promoting policies that reduce health disparities in low income communities of color by increasing access to healthy foods and promoting opportunities for physical activity. Banthia earned a BA in psychology from the University of California, Berkeley with a minor in South Asian Studies, and a PhD in behavioral medicine from the University of California San Diego/San Diego State University joint doctoral program in clinical psychology. She completed her clinical internship at the Veterans Affairs Palo Alto Health Care System and her postdoctoral fellowship at the University of California, San Francisco with funding from the W.K. Kellogg Scholars in Health Disparities program.

back to all staff

IvetteIvette S. Estay, PhD

Ivette S. Estay completed her PhD in Cancer Biology from the Stanford School of Medicine in 2009. In her dissertation work “Ubiquitin ligase regulation of Gli transcription factors”, Ivette, characterized cellular mechanisms that regulate the stability of Gli proteins. Gli proteins are the primary mediators of the Sonic Hedgehog (Shh) signaling pathway, a key developmental pathway that is aberrantly upregulated in basal cell carcinomas, the most common type of skin cancer. In addition to her thesis work at Stanford, Ivette has research experience in plant physiology, microbiology, and cardiovascular biology from a variety of institutions, California State University, Northridge, Harvard, and Agilent Technologies. Outside of the lab, she served the Stanford University community as a coordinator of the Cancer Biology High School Summer Program (2005-2008), Graduate Student Council Publicity Coordinator, Assistant Elections Commissioner for Graduate Elections, and Co-founder and Vice President of the Biomedical Association for the Interest of Minority Students. For fun, she enjoys entertaining friends, salsa dancing, hiking, art museums, and learning about other cultures. Ivette joined PMRI in 2009 and currently serves as Clinical Research Coordinator.

back to all staff

** PLEASE DESCRIBE THIS IMAGE **Melanie Elliott-Eller, RN, MSN

Melanie Elliott-Eller joined the PMRI clinical research team in 1991 as a cardiovascular clinical nurse specialist. She brings to the team a broad cardiovascular experience in the areas of nursing research, case management, cardiac critical care, cardiac rehabilitation, cardiovascular home health and hospice care, cardiovascular community wellness, integrative health, nursing education and quality assurance/performance improvement.

A cardiopulmonary Clinical Nurse Specialist by training, Melanie C. Elliott-Eller RN MSN CHTP is currently a research consultant for PMRI. She was the past Director of Site Operations and Nursing Services and National Site Consultant at the Preventive Medicine Research Institute and Lifestyle Advantage, LLC from 1993 to 2002. Responsibilities included the provision of quality monitoring processes for national sites operationalizing the Ornish Reversal Program; operational supervision as National Site Consultant for 11 sites; founder and director of nursing case management for the Ornish Reversal Program; clinical protocol development, implementation and monitoring according to professional and JCAHO standards; staff training and development; educational and operational material development; clinical nursing supervision of residential retreats; Project Director and co-investigator for the Beverage Studies I & II 2002 to 2005; co-investigator of Multicenter Lifestyle Modification Program Demonstration from 1993 through 1998; and was the Liaison for the Medicare Lifestyle Modification Program Demonstration from 1997 to 2002.

back to all staff

Tandis Tandis Alizadeh, BA

Tandis earned a bachelor's degree in Political Science from UC Davis. She comes to PMRI from the financial and software industries. Tandis currently serves as Project Coordinator at the Preventive Medicine Research Institute.

back to all staff

Jessica KniesJessica E. Knies, BA

Jessica currently serves as a part-time Administrative Assistant for the Institute while pursuing her certification to become a Master Pilates Instructor. Since graduating from the University of San Diego in 2004, Jessica has worked in the sales and member relations function within the health and wellness industry as well as recruiting for a boutique agency focusing on administrative professionals. Outside of work, Jessica enjoys hiking on Mt. Tam, entertaining friends, dance, yoga, pilates and nutrition.

back to all staff

Susi AmendolaSusi Amendola

From 1978-82, Susi lived as a resident of the Himalayan Institute where she attended classes in Hatha and Raja Yoga, Meditation, Yoga Philosophy, Ayurveda and numerous other health related topics. During her stay at the Institute she also taught Yogic cooking and managed the Vegetarian Kitchen . Upon moving to Omaha in 1982, she studied Iyengar-style yoga under the direction of Margo Pope. She has attended numerous yoga workshops around the country, studying a variety of styles, including: Flow, Asthanga, Restorative, and Iyengar yoga.

In 1984, she founded the Omaha Yoga & Bodywork Center, where she currently directs programs, and teaches classes. She has also developed a 200 teacher training program (registered with Yoga Alliance) as a way to support teachers and students in furthering their experiences in yoga.

In 1993-2004, she taught yoga as Stress Management through Immanuel Hospital's Heart Institute in Dr. Dean Ornish's program for reversing heart disease without drugs or surgery and currently serves as the National Director of Stress Management for the Ornish program hospital sites. She has developed yoga based Stress Management programs for schools, businesses and hospitals. She also teaches Yoga for credit at the University of Nebraska at Omaha. She continues to teach, study, practice, lecture and travel. Susi's new CD "Embrace the Heart of Yoga" is used in hospitals and schools across the country and is available on her website at www.doyoganow.com. Susi currently provides consulting services to PMRI.

back to all staff

Robert Avenson, PhD

Dr. Avenson is a licensed clinical psychologist in private practice in Albany, CA. He has been a facilitator for hundreds of Ornish groups since 1994. From 1999 through 2002 he served as the National Director of Psychological Services on the PMRI team that trained hospital staff to implement the Ornish Program. He has continued in this role from 2002 to the present for Highmark Blue Cross of Pennsylvania. He was the psychologist and group support facilitator for the two prostate cancer research studies run by PMRI and UCSF: The Prostate Cancer Lifestyle Trial, and The Gene Expression Modulation by Intervention Through Nutrition and Lifestyle Study. In addition to running groups, he presented lectures and demonstrations regarding the effects of the mind, emotions and social support on the body.

Bob is certified in Biofeedback. He is a Past President, Board Member Emeritus, and lecturer for The Norther California Society of Clinical Hypnosis. He has lectured at the University of California, Berkeley. He has served as a professor on the faculty of Alliant University, The California School of Professional Psychology where he taught the Advanced Clinical Seminar and Cognitive Behavioral Psychology. Bob is also currently working with Hills Physicians Medical Group to design and implement a chronic pain management program to train medical doctors, psychologists, and other health care practitioners to work in integrated wellness-oriented teams to address the spectrum of problems that confront patients with chronic pain. Robert currently provides consulting services to PMRI.

back to all staff

Stacey Dunn-EmkeStacey Dunn-Emke, MS, RD

Stacey is a Registered Dietitian with a Master's degree in Nutrition Science. Prior to joining PMRI in 1999, she was a nutrition educator, clinical dietitian, and clinical nutrition manager at several medical centers in the San Francisco Bay Area since 1991. Stacey frequently speaks on the topics of nutrition, diet and lifestyle. She has been invited to speak at Harvard Medical School, University of North Carolina at Chapel Hill, MD Anderson Cancer Center, Emory University, University of CA, San Francisco, the California Dietetic Association and the American Dietetic Association. She has appeared on the Oprah Winfrey Show and MSNBC TV. She has been featured in Weight Watchers magazine and Natural Health Magazine. Stacey has been active in professional associations by serving as the Bay Area Dietetic Association President and was awarded Outstanding Dietitian by the Bay Area Dietetic Association, Outstanding Dietitian of the Year by ARAMARK, Healthcare Support Services, and Recognized Young Dietitian of the Year by the California Dietetic Association. Stacey currently consults with the PMRI research team from her home in San Francisco, CA.

back to all staff

Joanne FrattaroliJoanne Frattaroli, PhD

Dr Frattaroli joined PMRI as a post-doctoral scholar in April of 2006. She is currently a Lecturer (PSOE) in the Department of Psychology and Social Behavior at UC Irvine. She earned her doctoral degree in Social-Personality Psychology from the University of California, Riverside in June of 2005. Her dissertation focused on experimental disclosure and its moderators. She graduated from Northeastern University in 1997 with a bachelor's degree in Psychology, earning the Psychology Faculty Award, Golden key National Honors Society, and Choral Society Organizational Leadership Award. At PMRI, Joanne focuses on the collection and analysis of survey and archival data concerning the effects of the Ornish Lifestyle Program on prostate cancer patients. Specifically, she analyzes the long-term clinical outcomes of the Prostate Cancer Lifestyle Trial. She is also studying the effects of lifestyle on angina symptoms in men and women with mild or limiting angina in the Multicenter Lifestyle Intervention Project.

back to all staff

Steven Frenda, BA

Steven Frenda joined PMRI as a Research Assistant after obtaining a Bachelors Degree in Psychology from The New School University in New York City. He served as data manager from 2006-2008 investigating health services outcomes and emerging cardiovascular disease biomarkers. He currently serves as data management consultant while pursuing his PhD in psychology at University of California, Irvine, studying memory.

back to all staff

Sarah GovilSarah Govil, MPH

Sarah graduated with a bachelor's degree in Biology from Carnegie Mellon University of Pittsburgh, Pennsylvania, in 2000. Before coming to PMRI, she was a research assistant at the Romberg Tiburon Center at San Francisco State University, investigating the potential influences of riverine and aeolian inputs on presence and nutrient uptake rates of phytoplankton and marine viruses. She joined PMRI in June of 2006 as a research intern while completing her Masters thesis in the Department of Epidemiology and Public Health at Yale University. Her public health Master's research examined health behavior changes in coronary heart disease patients with low socioeconomic status at PMRI under the supervision of Dr. Weidner. Her research interests include the effects of lifestyle change on risk factors and quality of life in secondary prevention of chronic diseases, especially cardiovascular diseases and cancers. She also has a strong interest in the role of socioeconomic status in the etiology, treatment, and prognosis of chronic disease. She currently contributes to the work at PMRI, examining clinical guidelines as they relate to diabetes and gender in the Multisite Cardiac Lifestyle Intervention Program, while she is enrolled in the Nurse Practitioner program at the School of Nursing at Yale University.

back to all staff

Michael Lee - focus97Michael Lee, BS

Michael graduated with a bachelor's degree in Physiology from UC Davis in 2003. After finishing research in cardiology, investigating the effects of the estrogen receptor alpha and its role in mediating heart disease, he moved to New York City in late 2003. There, he began work with a team at Columbia/Presbyterian hospital, supporting a clinical study in Acute Liver Failure at the Center for Liver Disease and Transplantation. Moving back to the San Francisco Bay Area, he began work in his own creative company - www.focus97.com - and also began research in a basic science lab at UCSF in the Dept. of Anesthesia, investigating anesthesia's effects on neurogenesis. Michael co-authored four papers with this lab before moving to a clinical studies lab at UCSF investigating and testing the accucary of pulse-oximeters capable of non-invasively detecting the presence of methemoglobin. While much of Michael's interests rest in medicine, his company has branded and built contemporary websites for industries across the country, ranging from medical, non-profit, financial, fashion, art, legal, and educational. Michael's principal contributions to PMRI are focused on web development.

back to all staff

Lee LipsenthalLee Lipsenthal, MD, ABIHM

Lee Lipsenthal is an internist with postgraduate training in cholesterol disorders and served as the Medical Director of the Preventive Medicine Research Institute for ten years. His research area is heart disease prevention. Dr. Lipsenthal consults with major medical centers, health research organizations, and corporations on health and wellness. He also teaches workshops and faculty, world-wide in the area of health care provider health, working with major organizations such as Kaiser-Permanente, Cleveland Clinic as well as many large universities, hospitals and medical groups (www.FindingBalancePrograms.com). He has served as the President of the American Board of Holistic Medicine and serves on the Board of Directors for the Institute of Noetic Sciences and HeartMath. Dr. Lipsenthal also serves on the American Medical Association's "Physician Wellness Committee". Lee currently provides consulting services to PMRI.

back to all staff

Ruth MarlinRuth Marlin, MD

Ruth Marlin is a board certified internist with training at the University of Tennessee, the Mayo Clinic and the University of British Columbia. She worked in private practice for many years, with a strong emphasis on prevention and patient education and has given numerous lectures on lifestyle factors in heart disease, diabetes and prostate cancer. For 15 years, she worked with Dr. Dean Ornish at the Preventive Medicine Research Institute as a lifestyle retreat physician; as the Medical Director of the Prostate Cancer Lifestyle and Geminal Trials in collaboration with the University of California and Memorial Sloan Kettering Cancer Center; and as the Director of Medical Education. Dr. Marlin is presently the Associate Director of the Northern California Melanoma Center at St. Mary's Medical Center in San Francisco where she also offers Integrative Medicine consultations. She is a diplomat of the American Board of Holistic Medicine and a member of the American College of Physicians and the Society for Integrative Oncology. Dr Marlin continues to provide consulting services with PMRI.

back to all staff

Jennifer McCreaJennifer McCrea, MA

Jennifer McCrea is the founder and president of Sarvada Consulting, a firm she formed to guide high net worth individuals and visionary leaders to rigorously and creatively leverage their philanthropic endeavors. Some of her current clients include the Quincy Jones Foundation, Millennium Promise, Mailman School of Public Health at Columbia University and Harvard School of Public Health. Previously, Jennifer spent 16 years as an academic fundraiser at Case Western Reserve University, Washington University in St. Louis and, most recently, at Dickinson College, where she served as Vice President for Development. She earned a B.A. from Allegheny College and a Master's degree in Nonprofit Management from Case Western Reserve University. From 2004-2009 she served as Executive Vice President of External Relations at PMRI. She currently provides consulting services to PMRI.

back to all staff

Terri Merritt-WordenTerri Merritt-Worden, MS, CES, FAACVPR

Terri received her BS in physical education at the State University of New York at Buffalo and her MS in exercise science at the University of Arizona. She has been actively involved in cardiac rehabilitation and intensive lifestyle modification research for over two decades and is most well known for her work with Dean Ornish, MD and the development of hospital based intensive lifestyle modification programs. Terri is a member of American College of Sports Medicine (ACSM), and has served on the Board of Director's of the American Heart Association- San Francisco Division, the California Society of Cardiac Rehabilitation (CSCR) and AACVPR. She is also an American College of Sports Medicine Certified Exercise Specialist, a certified Integral Yoga Institute instructor and a fellow of the American Association of Cardiovascular and Pulmonary Rehabilitation. In 2002 she received the AACVPR Distinguished Service Award and completed the Cardiovascular Health Fellowship with the Health Forum/American Hospital Association. In 2008 she accepted a position as Director of Health Management with the Wellspring Medical Center, part of the Silverton Hospital Network in Silverton, Oregon. She currently consults with PMRI from her home in Oregon.

back to all staff

Kathy Ornish, BS, MFA, CYT

Kathy Ornish, sister to Dean, currently lives in Lansing, Michigan, is a practicing certified yoga therapist and teacher, and a member of the International Association of Yoga Therapists. She completed the 500 hour Yoga Therapy Program and the 500 hour Advanced Teacher Training Program through Gary Kraftsow's American Viniyoga Institute (A.V.I.). Viniyoga evolved out of the teachings transmitted by T. Krishnamacharya and T.K.V. Desikachar of Madras, India. Formerly, she was a Professor of sculpture and ceramics for ten years.

Her primary emphasis is on teaching the breadth of the yoga tradition with the appropriate application of the many tools of yoga (physical postures, breathing, relaxation, meditation, lifestyle, chanting, and visualization). These tools are adapted to fit the need and unique condition of the individual, thereby assisting movement toward wellness at all levels (physically, emotionally, intellectually, and spiritually). Kathy hopes she can help people realize their highest potential and is honored to help them get a glimpse into the best that they already are (www.kathyornish.com ). Kathy currently provides consulting services to PMRI.

back to all staff

Claudia Pischke, PhD

Dr Pischke joined PMRI in 2005 as a pre-doctoral research scholar where she conducted her dissertation research. She graduated in Psychology from Philipps University of Marburg, Germany, in 1999 and was trained as a Health Psychologist at the Free University Berlin, Germany, where she received her Master's degree in Health Psychology in 2003. She also performed part of her master's level research on health behavior changes in coronary heart disease (CHD) patients with diabetes mellitus (DM) at PMRI under the supervision of Drs. Weidner and Schwarzer. Before coming to PMRI, she was a research assistant at the Department of Health Psychology at the Free University Berlin, investigating the effects of cognitive processes and depression on health behavior change in patients with CHD. She also completed an internship in the Department of Social Psychology of the University of California, Santa Cruz with Dr. Faye Crosby. Her research interests include the effects of lifestyle change on risk factors and quality of life in secondary prevention of diabetes, coronary heart disease, and heart failure. She also has a strong interest in the role of gender and sex differences in the etiology and prognosis of chronic disease. In July of 2008 Dr Pischke accepted a position as Post Doctoral Scholar at the School of Public Health at Harvard University. She currently contributes to PMRI, examining the effects of comprehensive lifestyle changes in relation to depression and coronary risk factors in men and women with elevated coronary risk factors.

back to all staff

Gerdi Weidner, PhD

Gerdi Weidner, PhDDr. Weidner joined PMRI in 2001 from the State University of New York at Stony Brook, where she was Professor of Psychology and Preventive Medicine (from 1984-2001). As Vice President and Director of Research at PMRI, she directed the research programs on cardiovascular disease and prostate cancer until May 2009, when she returned to an academic position in the Biology Department at San Francisco State University. She also conducts research at the Johannes Gutenberg-University in Mainz, Germany, where she was awarded an Alexander von Humboldt Research Prize and a Mercator Professorship from the German Research Foundation (Deutsche Forschungsgemeinschaft). She continues her affiliation with PMRI as a consultant.

Dr. Weidner’s research examines the role of stress, environment and gender in the etiology and treatment of chronic diseases, such as cardiovascular disease, diabetes mellitus, and cancer. She collaborates with investigators from a variety of disciplines (e.g., psychology, medicine, public health, epidemiology). Her research has been funded by NIH, the American Heart Association, DAAD, NATO, the German Research Foundation, and Eurotransplant.

back to all staff

History

For more than 30 years, Dean Ornish, M.D. and his colleagues at the non-profit Preventive Medicine Research Institute (PMRI) in collaboration with the University of California, San Francisco and other leading academic institutions, have conducted a series of research studies showing that changes in diet and lifestyle can make a powerful difference in our health and well-being, how quickly these changes may occur, and how dynamic these mechanisms can be.

Part of the value of this scientific research is that it raises awareness and redefines what is possible, giving many people new hope and new choices. Before, these research findings were thought to have been impossible. They show that your body often has a remarkable capacity to begin healing itself, and much more quickly than had once been thought possible.

Many people tend to think of breakthroughs in medicine as a new drug, laser, or high-tech surgical procedure. They often have a hard time believing that the simple choices that we make in our lives each day-what we eat, how we respond to stress, whether or not we smoke cigarettes, how much exercise we get, and the quality of our relationships and social support-can be as powerful as drugs and surgery, but they often are. Sometimes, even better.

Dr. Ornish and his colleagues conducted a series of randomized controlled trials and demonstration projects showing that these comprehensive changes in diet and lifestyle are both medically effective and cost effective. They used the latest in high-tech, state-of-the-art diagnostic technology to prove the power of these low-tech, low-cost, and ancient interventions.

They were the first to prove that the progression of coronary heart disease is often reversible by making comprehensive lifestyle changes. They showed, also for the first time, that these lifestyle changes may stop or even reverse the progression of early-stage prostate cancer. What affects prostate cancer is likely to affect breast cancer as well.

Dr. Ornish began conducting research in 1977, when he was a second-year medical student at the Baylor College of Medicine in Houston. While studying bypass surgery with Dr. Michael DeBakey, he wondered what might happen if people addressed the underlying lifestyle factors that often cause coronary heart disease rather than just literally or figuratively bypassing the problem with surgery or a lifetime of medications. He took a year off from medical school to conduct a pilot study of 10 patients with severe heart disease. After only one month, he found that blood flow to the heart improved and the frequency of angina (chest pain) diminished by over 90%. This study was published in the journal Clinical Research.

He returned to medical school and received his M.D. in 1980. He took another year off from his medical training to conduct a randomized controlled trial of this program in men and women with heart disease. He and his colleagues replicated the earlier findings and found that the ability of the heart to pump blood improved significantly after only one month. These findings were published in the Journal of the American Medical Association in 1983.

After finishing his internship and residency in internal medicine at the Massachusetts General Hospital and Harvard Medical School in June 1984, Dr. Ornish moved to San Francisco and founded the non-profit Preventive Medicine Research Institute later that year. He and his colleagues began conducting the Lifestyle Heart Trial, a randomized controlled trial designed to study the effects of these comprehensive lifestyle changes using two state-of-the-art measures: quantitative coronary arteriography to measure coronary artery blockages, and cardiac PET scans to measure blood flow to the heart.

After one year, the amount of coronary artery blockages (atherosclerosis) showed significant reversal (improvement) after only year. In contrast, the amount of coronary atherosclerosis increased (worsened) significantly in the comparison group of patients who were not making these changes in diet and lifestyle. This study was published in The Lancet in 1990 and was the subject of an award-winning one-hour documentary on NOVA, the PBS science series.

Based on these findings, the National Heart, Lung, and Blood Institute of the National Institutes of Health provided funding to extend the Lifestyle Heart Trial for four more years. They found even more reversal of coronary atherosclerosis after five years than after one year in the group of patients who made comprehensive lifestyle changes, whereas the disease severity continued to worsen in the comparison group of patients who were not making these changes in diet and lifestyle. They also found 2.5 times fewer cardiac events such as heart attacks, bypass surgery, or angioplasty in these patients when compared to the control group. This study was published in the Journal of the American Medical Association in 1998 and also in other medical journals as well. This study was featured in Bill Moyers' PBS series, Healing and the Mind, as well as in virtually all national media.

In 1993, PMRI began a series of demonstration projects to determine if diverse populations throughout the U.S. would be able to make and maintain these comprehensive lifestyle changes. Mutual of Omaha became the first major insurance company to cover Dr. Ornish's lifestyle program and the first insurer to cover any type of integrative medicine program. PMRI began the landmark Multicenter Lifestyle Demonstration Project, which involved patients from medical centers in four academic medical centers (Harvard's Beth Israel and Deaconess Hospitals, UCSF, Scripps, and Beth Israel Medical Center in New York) and four community hospitals (in Omaha, Nebraska; Columbia, South Carolina; Ft. Lauderdale, and Boston).

In this demonstration project, they found that almost 80% of people who were eligible for bypass surgery or angioplasty were able to safely avoid it by following Dr. Ornish's guidelines. Mutual of Omaha calculated saving almost $30,000/patient in the first year.

In a second demonstration project, Highmark Blue Cross Blue Shield compared patients who went through Dr. Ornish's program for reversing heart disease to a similar group of patients who did not. They found that overall health care costs declined by 50% after only one year and by an additional 20-30% when compared to a matched control group.

Based on these findings, the Centers for Medicare and Medicaid Services began a demonstration project to determine the effects of these comprehensive lifestyle changes in Medicare beneficiaries with coronary heart disease. These findings in over 2,000 patients were reviewed in a formal Medicare Coverage Advisory Commission hearing on January 25, 2005. Based on these outcomes, Medicare agreed to cover Dr. Ornish's program for reversing heart disease, the first time Medicare has covered an integrative medicine program, thereby making this program available in a sustainable way to those who most need it.

In 2005, in collaboration with Dr. Peter Carroll (chair of urology, UCSF) and Dr. William Fair (chair of urology and urologic oncology at Memorial Sloan-Kettering Cancer Center), Dr. Ornish and his colleagues at PMRI published the first randomized controlled trial showing that the progression of early-stage prostate cancer may be stopped or even reversed by making these comprehensive lifestyle changes. This was the first randomized controlled trial showing that the progression of any type of cancer may be stopped or reversed by making lifestyle changes. What is true for prostate cancer is likely to be true for breast cancer as well.

In 2008, PMRI and UCSF published the first study showing that these comprehensive lifestyle changes may beneficially affect gene expression in men with early prostate cancer-"turning on" or upregulating disease-preventing genes, and "turning off" or downregulating genes that promote breast cancer, heart disease, and chronic inflammation. This study was published in the Proceedings of the National Academy of Sciences.

They also showed that this program may significantly increase telomerase, and thus telomere length, by almost 30% in only three months, which is the first study showing that any intervention may increase telomerase. This study was conducted in collaboration with Dr. Elizabeth Blackburn, a professor at UCSF who received the Lasker Prize for discovering telomerase. Telomeres are the ends of chromosomes that control how long we live. As our telomeres get longer, so do our lives. This study was published in The Lancet Oncology.

PMRI continues to conduct leading-edge scientific research and to form strategic alliances to make this work available worldwide.